ABCB1 C3435T polymorphism and the risk of resistance to antiepileptic drugs in epilepsy: A systematic review and meta-analysis

@article{Haerian2010ABCB1CP,
  title={ABCB1 C3435T polymorphism and the risk of resistance to antiepileptic drugs in epilepsy: A systematic review and meta-analysis},
  author={Batoul Sadat Haerian and Harun Roslan and Azman Ali Raymond and Chong Tin Tan and Kil Seob Lim and Siti Zulaikha Zulkifli and E.H.M. Mohamed and Hui Jeen Tan and Zahurin Mohamed},
  journal={Seizure},
  year={2010},
  volume={19},
  pages={339-346}
}
OBJECTIVE The C3435T, a major allelic variant of the ABCB1 gene, is proposed to play a crucial role in drug-resistance in epilepsy. The C/C genotype carriers reportedly are at higher risk of pharmacoresistance to AEDs, but only in some studies. The hypothesis of the C-variant associated risk and resistance to antiepileptic drugs (AEDs) has been hampered by conflicting results from inadequate power in case-control studies. To assess the role of C3435T polymorphism in drug-resistance in epilepsy… CONTINUE READING

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