ABCB1 C3435T and G2677T/A polymorphism decreased the risk for steroid-induced osteonecrosis of the femoral head after kidney transplantation.

@article{Asano2003ABCB1CA,
  title={ABCB1 C3435T and G2677T/A polymorphism decreased the risk for steroid-induced osteonecrosis of the femoral head after kidney transplantation.},
  author={Takeshi Asano and Kenji A. Takahashi and Mikihiro Fujioka and Shigehiro Inoue and Masahiko Okamoto and Nobuyuki Sugioka and Hoyoku Nishino and Takashi Tanaka and Yoshio Hirota and Toshikazu Kubo},
  journal={Pharmacogenetics},
  year={2003},
  volume={13 11},
  pages={
          675-82
        }
}
Advances in transplantation technology have brought about great benefits to patients suffering from organ failure, but the problem still remains of complications induced by steroids used for post-transplant immunosuppression. Among the side-effects caused by steroids, non-traumatic osteonecrosis of the femoral head (ONF) constitutes a serious problem. The same protocol for steroid administration induces ONF in some patients, but not in others, indicating the presence of individual difference in… CONTINUE READING
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Clinical and basic research on steroid-induced osteonecrosis of the femoral head in Japan.

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