ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder.

@article{Kato2008ABCB1G,
  title={ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder.},
  author={Masaki Kato and Tsuyoshi Fukuda and Alessandro Serretti and Masataka Wakeno and Gaku Okugawa and Yuka Ikenaga and Yuka Hosoi and Y Takekita and Laura Mandelli and Junichi Azuma and Toshihiko Kinoshita},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2008},
  volume={32 2},
  pages={398-404}
}
Variability in antidepressant response is due to genetic and environmental factors. Among genetic factors, the ones controlling for availability of the drug at the target site are interesting candidates. Multidrug resistance 1 (ABCB1, MDR1) gene encodes a blood-brain barrier transporter P-glycoprotein that plays an important role in controlling the passage of substances between the blood and brain. In the present study, we therefore examined the possible association of 3 functional ABCB1… CONTINUE READING
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