ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology.

  title={ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology.},
  author={Nobutaka Sakae and Chia-Chen Liu and Mitsuru Shinohara and Jessica L Frisch-Daiello and Li Ma and Yu Yamazaki and Masaya Tachibana and Linda H. Younkin and Aishe Kurti and Minerva M. Carrasquillo and Fanggeng Zou and Daniel Sevlever and Gina D. Bisceglio and Ming Gan and Romain Fol and Patrick D Knight and Miao Wang and Xianlin Han and John D Fryer and Michael L. Fitzgerald and Yasumasa Ohyagi and Steven G. Younkin and Guojun Bu and Takahisa Kanekiyo},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={36 13},
UNLABELLED In Alzheimer's disease (AD), the accumulation and deposition of amyloid-β (Aβ) peptides in the brain is a central event. Aβ is cleaved from amyloid precursor protein (APP) by β-secretase and γ-secretase mainly in neurons. Although mutations inAPP,PS1, orPS2cause early-onset familial AD,ABCA7encoding ATP-binding cassette transporter A7 is one of the susceptibility genes for late-onset AD (LOAD), in which itsloss-of-functionvariants increase the disease risk. ABCA7 is homologous to a… CONTINUE READING
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