ABCA1 mediates high-affinity uptake of 25-hydroxycholesterol by membrane vesicles and rapid efflux of oxysterol by intact cells.

@article{Tam2006ABCA1MH,
  title={ABCA1 mediates high-affinity uptake of 25-hydroxycholesterol by membrane vesicles and rapid efflux of oxysterol by intact cells.},
  author={S Tam and Leo Mok and Giovanna Chimini and Monika Vasa and R. G. Deeley},
  journal={American journal of physiology. Cell physiology},
  year={2006},
  volume={291 3},
  pages={C490-502}
}
ATP Binding Cassette (ABC) transporter, ABCA1, plays a pivotal role in reverse cholesterol transport by mediating the cellular efflux of phospholipid and cholesterol. Studies using intact cells strongly suggest that ABCA1 acts as a phospholipid floppase, but there has been no direct demonstration that the protein is a primary active sterol transporter. Using membrane vesicles from insect Sf21 cells, we found that ABCA1 mediated ATP-dependent uptake of [(3)H]25-hydroxycholesterol with an… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Lipid transport by mammalian ABC proteins.

Essays in biochemistry • 2011
View 8 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…