ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.

@article{Wahrle2004ABCA1IR,
  title={ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.},
  author={Suzanne Elizabeth Wahrle and Hong Jiang and Maia Parsadanian and Justin Legleiter and Xianlin Han and John D Fryer and Tomasz Kowalewski and David M Holtzman},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 39},
  pages={40987-93}
}
ABCA1 is an ATP-binding cassette protein that transports cellular cholesterol and phospholipids onto high density lipoproteins (HDL) in plasma. Lack of ABCA1 in humans and mice causes abnormal lipidation and increased catabolism of HDL, resulting in very low plasma apoA-I, apoA-II, and HDL. Herein, we have used Abca1-/- mice to ask whether ABCA1 is involved in lipidation of HDL in the central nervous system (CNS). ApoE is the most abundant CNS apolipoprotein and is present in HDL-like… CONTINUE READING
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