ABCA1 gene promoter DNA methylation is associated with HDL particle profile and coronary artery disease in familial hypercholesterolemia.

@article{Guay2012ABCA1GP,
  title={ABCA1 gene promoter DNA methylation is associated with HDL particle profile and coronary artery disease in familial hypercholesterolemia.},
  author={Simon-Pierre Guay and Diane Prud'homme Brisson and Johannie Munger and Beno{\^i}t Lamarche and Daniel Gaudet and Luigi Bouchard},
  journal={Epigenetics},
  year={2012},
  volume={7 5},
  pages={464-72}
}
High-density lipoproteins cholesterol (HDL-C) level, a strong coronary artery disease (CAD) clinical biomarker, shows significant interindividual variability. However, the molecular mechanisms involved remain mostly unknown. ATP-binding cassette A1 (ABCA1) catalyzes the cholesterol transfer from peripheral cells to nascent HDL particles. Recently, a differentially methylation region was identified in ABCA1 gene promoter locus, near the first exon. Therefore, we hypothesized that DNA methylation… CONTINUE READING

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