ABCA1 and biogenesis of HDL.

  title={ABCA1 and biogenesis of HDL.},
  author={Shinji Yokoyama},
  journal={Journal of atherosclerosis and thrombosis},
  volume={13 1},
Mammalian somatic cells do not catabolize cholesterol and therefore export it for sterol homeostasis at cell and whole body levels. This mechanism may reduce intracellularly accumulated excess cholesterol, and thereby would contribute to the prevention or cure of the initial stage of atherosclerotic vascular lesion. High-density lipoprotein (HDL) plays a central role in this reaction by removing cholesterol from cells and transporting it to the liver, the major cholesterol catabolic site. Two… CONTINUE READING


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