ABCA1: regulation, trafficking and association with heteromeric proteins.

  title={ABCA1: regulation, trafficking and association with heteromeric proteins.},
  author={Gerd Schmitz and Christa Buechler},
  journal={Annals of medicine},
  volume={34 5},
HDL metabolism is crucial in maintaining cellular cholesterol and phospholipid homeostasis and prevention of atherosclerosis progression. Recent work identified the ATP-binding cassette transporter A1 (ABCA1) as the major regulator of plasma high density lipoprotein (HDL) cholesterol responsible for the removal of excess cholesterol from peripheral cells and tissues. Here we discuss some novel aspects of the ABCA1 network: 1) the cellular pathways involved in cholesterol and phospholipid efflux… CONTINUE READING


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