ABCA transporter gene expression and poor outcome in epithelial ovarian cancer.

@article{Hedditch2014ABCATG,
  title={ABCA transporter gene expression and poor outcome in epithelial ovarian cancer.},
  author={Ellen L Hedditch and Bo Gao and Amanda J Russell and Yi Chien Lu and Catherine Emmanuel and Jonathan Beesley and Sharon E Johnatty and Xiaoqing Chen and Paul Harnett and Joshy Chalil George and Rebekka T Williams and Claudia L. Flemming and Diether Lambrechts and Evelyn Despierre and Sandrina Lambrechts and Ignace Vergote and Beth Karlan and Jenny Lester and Sandra Orsulic and Christine M. Walsh and Peter A. Fasching and Matthias Wilhelm Beckmann and Arif B. Ekici and Alexander Hein and Keitaro Matsuo and Satoyo Hosono and Toru Nakanishi and Yasushi Yatabe and Tanja Pejovi{\'c} and Yukie T. Bean and Florian Heitz and Philipp Harter and Andreas Du Bois and Ira Schwaab and Estrid Hogdall and Susan Kr{\"u}ger Kjaer and Allan Jensen and Claus Hogdall and Lene Lundvall and Svend Aage Engelholm and Bob Brown and James Flanagan and Michelle Metcalf and Nadeem Siddiqui and Thomas Sellers and Brooke L. Fridley and Julie Cunningham and Joellen M Schildkraut and Ed Iversen and Rachel Palmieri Weber and Andrew Berchuck and Ellen L. Goode and David D. L. Bowtell and Georgia Chenevix-Trench and Anna deFazio and Murray D Norris and Stuart A Macgregor and Michelle Haber and Michelle J. Henderson},
  journal={Journal of the National Cancer Institute},
  year={2014},
  volume={106 7}
}
BACKGROUND ATP-binding cassette (ABC) transporters play various roles in cancer biology and drug resistance, but their association with outcomes in serous epithelial ovarian cancer (EOC) is unknown. METHODS The relationship between clinical outcomes and ABC transporter gene expression in two independent cohorts of high-grade serous EOC tumors was assessed with real-time quantitative polymerase chain reaction, analysis of expression microarray data, and immunohistochemistry. Associations… CONTINUE READING

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