ABC transporters required for endocytosis and endosomal pH regulation in Dictyostelium.

@article{Brazill2001ABCTR,
  title={ABC transporters required for endocytosis and endosomal pH regulation in Dictyostelium.},
  author={Derrick T Brazill and Laurence R. Meyer and Robin D Hatton and Debra A Brock and Richard H Gomer},
  journal={Journal of cell science},
  year={2001},
  volume={114 Pt 21},
  pages={3923-32}
}
In Dictyostelium, the RtoA protein links both initial cell-type choice and physiological state to cell-cycle phase. rtoA- cells (containing a disruption of the rtoA gene) generally do not develop past the mound stage, and have an abnormal ratio of prestalk and prespore cells. RtoA is also involved in fusion of endocytic/exocytic vesicles. Cells lacking RtoA, although having a normal endocytosis rate, have a decreased exocytosis rate and endosomes with abnormally low pHs. RtoA levels vary during… CONTINUE READING