ABC transporters during epilepsy and mechanisms underlying multidrug resistance in refractory epilepsy.

@article{Lazarowski2007ABCTD,
  title={ABC transporters during epilepsy and mechanisms underlying multidrug resistance in refractory epilepsy.},
  author={Alberto Jorge Lazarowski and Liliana Czornyj and Fabiana Lubienieki and Elena Silvia Girardi and Silvia V{\'a}zquez and Carlos D'Giano},
  journal={Epilepsia},
  year={2007},
  volume={48 Suppl 5},
  pages={140-9}
}
It is estimated 20-25% of the epileptic patients fails to achieve good control with the different antiepileptic drugs (AEDs) treatments, developing refractory epilepsy (RE). Discovered first in cancer, the activity of P-glycoprotein (P-gp) and others ABC transporters as multidrug-resistance-associated proteins (MRPs) and breast cancer resistant protein (BCRP) are directly related with the refractoriness. We have observed the overexpression of these all transporters in the brain of patients with… CONTINUE READING

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