ABC transporter inhibitors that are substrates enhance lentiviral vector transduction into primitive hematopoietic progenitor cells.

@article{Davis2004ABCTI,
  title={ABC transporter inhibitors that are substrates enhance lentiviral vector transduction into primitive hematopoietic progenitor cells.},
  author={Brian M. Davis and Laurent Humeau and Vladimir Slepushkin and Gwendolyn Binder and Lauren Korshalla and Yajin Ni and E Oluwakemi Ogunjimi and Liuyi Chang and Xiaobin Lu and Boro Dropuli{\'c}},
  journal={Blood},
  year={2004},
  volume={104 2},
  pages={
          364-73
        }
}
High gene transfer efficiencies have been difficult to achieve in hematopoietic progenitor cells (HPCs) but are important to therapeutic success of HPC gene therapy. Efficient gene transfer is especially challenging with use of column-purified vector for clinical application, as opposed to centrifuged vector commonly used for research. We investigated novel approaches to increase transduction by using a clinically applicable protocol and quantities of column-purified lentiviral vector… CONTINUE READING

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Largescale purification of a lentiviral vector by size exclusion chromatography or mustang Q ion exchange capsule

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