ABC transporter Cdr1p contributes more than Cdr2p does to fluconazole efflux in fluconazole-resistant Candida albicans clinical isolates.

@article{Holmes2008ABCTC,
  title={ABC transporter Cdr1p contributes more than Cdr2p does to fluconazole efflux in fluconazole-resistant Candida albicans clinical isolates.},
  author={Ann R. Holmes and Ya-Hsun Lin and Kyoko Niimi and Erwin Lamping and Mikhail V. Keniya and Masakazu Niimi and Koichi Tanabe and Brian C Monk and Richard David Cannon},
  journal={Antimicrobial agents and chemotherapy},
  year={2008},
  volume={52 11},
  pages={3851-62}
}
Fluconazole (FLC) remains the antifungal drug of choice for non-life-threatening Candida infections, but drug-resistant strains have been isolated during long-term therapy with azoles. Drug efflux, mediated by plasma membrane transporters, is a major resistance mechanism, and clinically significant resistance in Candida albicans is accompanied by increased transcription of the genes CDR1 and CDR2, encoding plasma membrane ABC-type transporters Cdr1p and Cdr2p. The relative importance of each… CONTINUE READING
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