ABC multidrug transporters: target for modulation of drug pharmacokinetics and drug-drug interactions.

Abstract

Nine proteins of the ABC superfamily (P-glycoprotein, 7 MRPs and BCRP) are involved in multidrug transport. Being localised at the surface of endothelial or epithelial cells, they expel drugs back to the external medium (if located at the apical side [P-glycoprotein, BCRP, MRP2, MRP4 in the kidney]) or to the blood (if located at the basolateral side [MRP1… (More)

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Cite this paper

@article{Marquez2011ABCMT, title={ABC multidrug transporters: target for modulation of drug pharmacokinetics and drug-drug interactions.}, author={B{\'e}atrice Marquez and Françoise Van Bambeke}, journal={Current drug targets}, year={2011}, volume={12 5}, pages={600-20} }