ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation.

@article{Shirihai2000ABCmeAN,
  title={ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation.},
  author={Orian S Shirihai and Thomas F. Gregory and Changpu Yu and Stuart H Orkin and Mitchell J Weiss},
  journal={The EMBO journal},
  year={2000},
  volume={19 11},
  pages={
          2492-502
        }
}
Transcription factor GATA-1 is essential for normal erythropoiesis. GATA-binding sites are consistently found in promoters or enhancers of genes expressed selectively in erythroid cells. To discover novel GATA-1-regulated genes, we searched for GATA-1-activated transcripts in G1E cells, an erythroid line derived from GATA-1(-) embryonic stem cells. By subtractive analysis, we identified a new ATP-binding cassette (ABC) transporter that is strongly and rapidly induced by GATA-1. This protein… CONTINUE READING
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