ABC drug transporters and immunity: novel therapeutic targets in autoimmunity and cancer.

  title={ABC drug transporters and immunity: novel therapeutic targets in autoimmunity and cancer.},
  author={Rieneke van de Ven and Ruud Oerlemans and Joost W. van der Heijden and George L. Scheffer and Tanja D. de Gruijl and Gerrit Jansen and Rik J. Scheper},
  journal={Journal of leukocyte biology},
  volume={86 5},
ABC transporters were identified originally for their contribution to clinical MDR as a result of their capacity to extrude various unrelated cytotoxic drugs. More recent reports have shown that ABC transporters can play important roles in the development, differentiation, and maturation of immune cells and are involved in migration of immune effector cells to sites of inflammation. Many of the currently identified, endogenous ABC transporter substrates have immunostimulating effects… CONTINUE READING

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