ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair

Abstract

The Rad50 ABC–ATPase complex with Mre11 nuclease is essential for dsDNA break repair, telomere maintenance and ataxia telangiectasia–mutated kinase checkpoint signaling. How Rad50 affects Mre11 functions and how ABC–ATPases communicate nucleotide binding and ligand states across long distances and among protein partners are questions that have remained… (More)
DOI: 10.1038/nsmb0312-364a

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Cite this paper

@inproceedings{Williams2011ABCAS, title={ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair}, author={G. Williams and R Scott Williams and Jessica S. Williams and Gabriel Moncali{\'a}n and Andy Arvai and Oliver Limbo and Grant R. Guenther and Soumita Sildas and Michal Hammel and Paul Russell and John A. Tainer}, booktitle={Nature Structural &Molecular Biology}, year={2011} }