ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.

@article{Lustbader2004ABADDL,
  title={ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.},
  author={Joyce W. Lustbader and Maurizio Cirilli and Chang Sheng-Huei Lin and Hong Wei Xu and Kazuhiro Takuma and Ning Wang and Casper Caspersen and Xi Chen and Susan M. Pollak and Michael J. Chaney and Fabrizio Trinchese and ShuMin Liu and Frank Gunn-Moore and Lih-Fen Lue and Douglas G. Walker and Periannan Kuppusamy and Zay L Zewier and Ottavio Arancio and David Stern and Shirley ShiDu Yan and Hao Wu},
  journal={Science},
  year={2004},
  volume={304 5669},
  pages={448-52}
}
Mitochondrial dysfunction is a hallmark of beta-amyloid (Abeta)-induced neuronal toxicity in Alzheimer's disease (AD). Here, we demonstrate that Abeta-binding alcohol dehydrogenase (ABAD) is a direct molecular link from Abeta to mitochondrial toxicity. Abeta interacts with ABAD in the mitochondria of AD patients and transgenic mice. The crystal structure of Abeta-bound ABAD shows substantial deformation of the active site that prevents nicotinamide adenine dinucleotide (NAD) binding. An ABAD… CONTINUE READING
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