AAV9-mediated expression of a non-self protein in nonhuman primate central nervous system triggers widespread neuroinflammation driven by antigen-presenting cell transduction.

@article{Samaranch2014AAV9mediatedEO,
  title={AAV9-mediated expression of a non-self protein in nonhuman primate central nervous system triggers widespread neuroinflammation driven by antigen-presenting cell transduction.},
  author={Lluis Samaranch and Waldy San Sebasti{\'a}n and Adrian P. Kells and Ernesto A Aguilar Salegio and Gregory Heller and John R. Bringas and Philip J Pivirotto and Stephen J. DeArmond and John R. Forsayeth and Krystof S. Bankiewicz},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2014},
  volume={22 2},
  pages={329-337}
}
Many studies have demonstrated that adeno-associated virus serotype 9 (AAV9) transduces astrocytes and neurons when infused into rat or nonhuman primate (NHP) brain. We previously showed in rats that transduction of antigen-presenting cells (APC) by AAV9 encoding a foreign protein triggered a full neurotoxic immune response. Accordingly, we asked whether this phenomenon occurred in NHP. We performed parenchymal or intrathecal infusion of AAV9 encoding green fluorescent protein (GFP), a non-self… CONTINUE READING
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