AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial

@article{Lewitt2011AAV2GADGT,
  title={AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial},
  author={P. Lewitt and A. Rezai and M. Leehey and S. Ojemann and A. Feigin and S. Tatter},
  journal={The Lancet Neurology},
  year={2011},
  volume={10},
  pages={309-319}
}
  • P. Lewitt, A. Rezai, +3 authors S. Tatter
  • Published 2011
  • Medicine
  • The Lancet Neurology
  • BACKGROUND Gene transfer of glutamic acid decarboxylase (GAD) and other methods that modulate production of GABA in the subthalamic nucleus improve basal ganglia function in parkinsonism in animal models. We aimed to assess the effect of bilateral delivery of AAV2-GAD in the subthalamic nucleus compared with sham surgery in patients with advanced Parkinson's disease. METHODS Patients aged 30-75 years who had progressive levodopa-responsive Parkinson's disease and an overnight off-medication… CONTINUE READING
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    References

    SHOWING 1-10 OF 35 REFERENCES
    A Phase I Study of Aromatic L-Amino Acid Decarboxylase Gene Therapy for Parkinson's Disease.
    • 177
    A randomized trial of deep-brain stimulation for Parkinson's disease.
    • 2,080
    • PDF
    Subthalamic Glutamic Acid Decarboxylase Gene Therapy: Changes in Motor Function and Cortical Metabolism
    • M. Emborg, M. Carbon, +10 authors D. Eidelberg
    • Biology, Medicine
    • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
    • 2007
    • 117
    Subthalamic GAD Gene Therapy in a Parkinson's Disease Rat Model
    • 291
    Modulation of metabolic brain networks after subthalamic gene therapy for Parkinson's disease
    • 169
    • PDF
    Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease.
    • 950
    • PDF