AAV vector integration sites in mouse hepatocellular carcinoma.


Adeno-associated viruses (AAV) are promising gene therapy vectors that have little or no acute toxicity. We show that normal mice and mice with mucopolysaccharidosis VII (MPS VII) develop hepatocellular carcinoma (HCC) after neonatal injection of an AAV vector expressing b-glucuronidase. AAV proviruses were isolated from four tumors and were all located… (More)


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@article{Donsante2007AAVVI, title={AAV vector integration sites in mouse hepatocellular carcinoma.}, author={Anthony Donsante and Daniel G. Miller and Yi Li and Carole A. Vogler and Elizabeth M. Brunt and D. W. Russell and Mark Steven Sands}, journal={Science}, year={2007}, volume={317 5837}, pages={477} }