AAV serotype 8-mediated gene delivery of a soluble VEGF receptor to the CNS for the treatment of glioblastoma.

@article{Harding2006AAVS8,
  title={AAV serotype 8-mediated gene delivery of a soluble VEGF receptor to the CNS for the treatment of glioblastoma.},
  author={Thomas C. Harding and Alshad S. Lalani and Byron N. Roberts and Satya Yendluri and B Q Luan and Kathryn E. Koprivnikar and Melissa Gonzalez-Edick and Guang Huan-Tu and Randy Musterer and Melinda Vanroey and Tomoko Ozawa and R A Lecouter and Dennis F. Deen and Peter J. C. Dickinson and Karin Jooss},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2006},
  volume={13 5},
  pages={956-66}
}
The presence of the blood-brain barrier complicates drug delivery in the development of therapeutic agents for the treatment of glioblastoma multiforme (GBM). The use of local gene transfer in the brain has the potential to overcome this delivery barrier by allowing the expression of therapeutic agents directly at the tumor site. In this study, we describe the development of a recombinant adeno-associated (rAAV) serotype 8 vector that encodes an optimized soluble inhibitor, termed sVEGFR1/R2… CONTINUE READING
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