AAV-mediated knockdown of phospholamban leads to improved contractility and calcium handling in cardiomyocytes.

@article{Andino2008AAVmediatedKO,
  title={AAV-mediated knockdown of phospholamban leads to improved contractility and calcium handling in cardiomyocytes.},
  author={Lourdes M Andino and Morihiko Takeda and Hideko Kasahara and Andrew Jakymiw and Barry Byrne and Alfred S Lewin},
  journal={The journal of gene medicine},
  year={2008},
  volume={10 2},
  pages={132-42}
}
BACKGROUND Reduced contractility due to dysregulation of intracellular calcium (Ca(2+)) is a common pathologic feature of chronic heart failure. Calcium stores in the sarcoplasmic reticulum play a major role in regulating cardiac contractility. Several animal models of heart failure have been treated by altering the regulation of the sarcoplamic reticulum ATPase through ablation or down-regulation of its inhibitor peptide, phospholamban (PLN). METHODS We have designed two small hairpin RNAs… CONTINUE READING

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