AAV-mediated hippocampal expression of short and long Homer 1 proteins differentially affect cognition and seizure activity in adult rats.

@article{Klugmann2005AAVmediatedHE,
  title={AAV-mediated hippocampal expression of short and long Homer 1 proteins differentially affect cognition and seizure activity in adult rats.},
  author={Matthias Klugmann and Charlotte Symes and Claudia B. Leichtlein and Bettina K Klaussner and Jane Dunning and Dahna Fong and Deborah Young and Matthew John During},
  journal={Molecular and cellular neurosciences},
  year={2005},
  volume={28 2},
  pages={347-60}
}
Homer proteins mediate molecular rearrangements leading to changes in spine morphology. This points to a role of Homer in learning and memory. Homer 1c features both the ligand binding domain and a coiled-coiled domain for self-multimerization. Homer 1a lacks the coiled-coiled domain. Here, we report a new isoform which we termed 1g, lacking the Homer ligand binding domain. We dissected the functional roles of the individual Homer 1 domains, encoded by Homer 1a, 1c, and 1g, in vivo. Recombinant… CONTINUE READING

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