AAV delivery of mineralocorticoid receptor shRNA prevents progression of cold-induced hypertension and attenuates renal damage

@article{Wang2006AAVDO,
  title={AAV delivery of mineralocorticoid receptor shRNA prevents progression of cold-induced hypertension and attenuates renal damage},
  author={Xin Wang and Lucille Skelley and Robert Cade and Zhen Xing Sun},
  journal={Gene Therapy},
  year={2006},
  volume={13},
  pages={1097-1103}
}
The aim of this study was to determine the effect of RNA interference inhibition of mineralocorticoid receptor (MR) on cold-induced hypertension (CIH) and renal damage. Recombinant adeno-associated virus (AAV) carrying short hairpin small interference (si)RNA for MR (AAV.MR-shRNA) was constructed and tested for the ability to inhibit renal MR and to control CIH. Three groups of rats with CIH received AAV.MR-shRNA (1.25 × 109 particles/rat, intravenous), AAV carrying scrambled shRNA (AAV.Control… CONTINUE READING

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