AAV-Mediated Gene Transfer of the Obesity-Associated Gene Etv5 in Rat Midbrain Does Not Affect Energy Balance or Motivated Behavior

@inproceedings{Boender2014AAVMediatedGT,
  title={AAV-Mediated Gene Transfer of the Obesity-Associated Gene Etv5 in Rat Midbrain Does Not Affect Energy Balance or Motivated Behavior},
  author={Arjen J. Boender and Nivard A. Koning and Jos{\'e} K. van den Heuvel and Mieneke C. M. Luijendijk and Andrea J. van Rozen and Susanne E la Fleur and Roger A. H. Adan},
  booktitle={PloS one},
  year={2014}
}
Several genome-wide association studies have implicated the transcription factor E-twenty- six version 5 (Etv5) in the regulation of body mass index. Further substantiating the role of Etv5 in feeding behavior are the findings that targeted disruption of Etv5 in mice leads to decreased body weight gain and that expression of Etv5 is decreased in the ventral tegmental area and substantia nigra pars compacta (VTA/SNpc) after food restriction. As Etv5 has been suggested to influence dopaminergic… CONTINUE READING
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