AAV-KLF7 Promotes Descending Propriospinal Neuron Axonal Plasticity after Spinal Cord Injury

@inproceedings{Li2017AAVKLF7PD,
  title={AAV-KLF7 Promotes Descending Propriospinal Neuron Axonal Plasticity after Spinal Cord Injury},
  author={Wen-Yuan Li and Ying Wang and Feng-Guo Zhai and Ping Sun and Yong-Xia Cheng and Ling-Xiao Deng and Zhen-Yu Wang},
  booktitle={Neural plasticity},
  year={2017}
}
DPSN axons mediate and maintain a variety of normal spinal functions. Unsurprisingly, DPSN tracts have been shown to mediate functional recovery following SCI. KLF7 could contribute to CST axon plasticity after spinal cord injury. In the present study, we assessed whether KLF7 could effectively promote DPSN axon regeneration and synapse formation following SCI. An AAV-KLF7 construct was used to overexpress KLF7. In vitro, KLF7 and target proteins were successfully elevated and axonal outgrowth… CONTINUE READING
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