AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis.

@article{Page1999AATFAN,
  title={AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis.},
  author={Grit Page and Inga L{\"o}dige and Donat K{\"o}gel and Karl Heinz Scheidtmann},
  journal={FEBS letters},
  year={1999},
  volume={462 1-2},
  pages={187-91}
}
Dlk, also known as ZIP kinase, is a serine/threonine kinase that is tightly associated with nuclear structures. Under certain conditions, which require cytoplasmic localization, Dlk can induce apoptosis. In search for interaction partners that might serve as regulators or targets of this kinase we identified apoptosis antagonizing transcription factor (AATF), a nuclear phosphoprotein of 523 amino acids. The 1.8 kb mRNA seems to be ubiquitously expressed. AATF contains an extremely acidic domain… CONTINUE READING
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