AAF-cmk sensitizes tumor cells to trail-mediated apoptosis.


TRAIL is a member of the tumor necrosis factor (TNF) superfamily. This cytokine is cytotoxic for a high proportion of tumor cells, but could be also toxic for normal cells. There is a need to find other agents able to potentiate the antitumor effects of this cytokine. In our study, we found that Ala-Ala-Phe-chloromethylketone (AAF-cmk) augmented cytotoxic… (More)


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@article{Mnarczuk2004AAFcmkST, title={AAF-cmk sensitizes tumor cells to trail-mediated apoptosis.}, author={Izabela Młnarczuk and Paweł Mr{\'o}z and Grazyna Anna Hoser and Dominika A Nowis and Łukasz P Biały and Halina Ziemba and Tomasz Grzela and Wojciech Feleszko and Jacek Malejczyk and Cezary W{\'o}jcik and Marek Jak{\'o}bisiak and Jakub Gołąb}, journal={Leukemia research}, year={2004}, volume={28 1}, pages={53-61} }