AAC-11 Overexpression Induces Invasion and Protects Cervical Cancer Cells from Apoptosis

@article{Kim2000AAC11OI,
  title={AAC-11 Overexpression Induces Invasion and Protects Cervical Cancer Cells from Apoptosis},
  author={Jin Woo Kim and Hyun Suk Cho and Jeong Hyun Kim and Soo Young Hur and Tae Eung Kim and Joon Mo Lee and In-Kyung Kim and Sung Eun Namkoong},
  journal={Laboratory Investigation},
  year={2000},
  volume={80},
  pages={587-594}
}
To identify the genes involved in cervical carcinogenesis, we applied the mRNA differential display (DD) method to analyze normal cervical tissue, cervical cancer, metastatic lymph node, and cervical cancer cell line. We cloned a 491-bp cDNA fragment, CC231, which was present in metastatic tissue and cervical cancer cell line, but absent in normal cervical and cervical cancer tissues. The 491 bp cDNA fragment has 98% homology to the previously published sequence, AAC-11 (antiapoptosis clone 11… CONTINUE READING