AAA+ chaperone ClpX regulates dynamics of prokaryotic cytoskeletal protein FtsZ.

@article{Sugimoto2010AAACC,
  title={AAA+ chaperone ClpX regulates dynamics of prokaryotic cytoskeletal protein FtsZ.},
  author={Shinya Sugimoto and Kunitoshi Yamanaka and Shingo Nishikori and Atsushi Miyagi and Toshio Ando and Teru Ogura},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 9},
  pages={6648-57}
}
AAA(+) chaperone ClpX has been suggested to be a modulator of prokaryotic cytoskeletal protein FtsZ, but the details of recognition and remodeling of FtsZ by ClpX are largely unknown. In this study, we have extensively investigated the nature of FtsZ polymers and mechanisms of ClpX-regulated FtsZ polymer dynamics. We found that FtsZ polymerization is inhibited by ClpX in an ATP-independent manner and that the N-terminal domain of ClpX plays a crucial role for the inhibition of FtsZ… CONTINUE READING