AAA+ Ring and Linker Swing Mechanism in the Dynein Motor

@inproceedings{Roberts2009AAARA,
  title={AAA+ Ring and Linker Swing Mechanism in the Dynein Motor},
  author={Anthony J. Roberts and Naoki Numata and Matt L. Walker and Yusuke S. Kato and Bara Malkova and Takahide Kon and Reiko Ohkura and Fumio Arisaka and Peter John Knight and Kazuo Sutoh and Stan A. Burgess},
  booktitle={Cell},
  year={2009}
}
Dynein ATPases power diverse microtubule-based motilities. Each dynein motor domain comprises a ring-like head containing six AAA+ modules and N- and C-terminal regions, together with a stalk that binds microtubules. How these subdomains are arranged and generate force remains poorly understood. Here, using electron microscopy and image processing of tagged and truncated Dictyostelium cytoplasmic dynein constructs, we show that the heart of the motor is a hexameric ring of AAA+ modules, with… CONTINUE READING

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