AAA+ ATPases: Achieving Diversity of Function with Conserved Machinery

@article{White2007AAAAA,
  title={AAA+ ATPases: Achieving Diversity of Function with Conserved Machinery},
  author={Susan Roehl White and Brett P Lauring},
  journal={Traffic},
  year={2007},
  volume={8}
}
AAA+ adenosine triphosphatases (ATPases) are molecular machines that perform a wide variety of cellular functions. For instance, they can act in vesicle transport, organelle assembly, membrane dynamics and protein unfolding. In most cases, the ATPase domains of these proteins assemble into active ring‐shaped hexamers. As AAA+ proteins have a common structure, a central issue is determining how they use conserved mechanistic principles to accomplish specific biological actions. Here, we review… 
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