A986S polymorphism of the calcium-sensing receptor and circulating calcium concentrations.

@article{Cole1999A986SPO,
  title={A986S polymorphism of the calcium-sensing receptor and circulating calcium concentrations.},
  author={David E. C. Cole and Vanya D. Peltekova and Laurence A. Rubin and Gillian Hawker and Reinhold Vieth and Choong Chin Liew and D. M. Hwang and Jovan Evrovski and Geoffrey N Hendy},
  journal={Lancet},
  year={1999},
  volume={353 9147},
  pages={112-5}
}
BACKGROUND The regulation of extracellular calcium concentration by parathyroid hormone is mediated by a calcium-sensing, G-protein-coupled cell-surface receptor (CASR). Mutations of the CASR gene alter the set-point for extracellular ionised calcium [Ca2+]o and cause familial hypercalcaemia or hypocalcaemia. The CASR missense polymorphism, A986S, is common in the general population and is, therefore, a prime candidate as a genetic determinant of extracellular calcium concentration. METHODS… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 51 extracted citations

Similar Papers

Loading similar papers…