A5 cells are silenced when REM sleep-like signs are elicited by pontine carbachol.

@article{Fenik2002A5CA,
  title={A5 cells are silenced when REM sleep-like signs are elicited by pontine carbachol.},
  author={Victor B. Fenik and Vitaliy Marchenko and Patrick Janssen and Richard O. Davies and Leszek Kubin},
  journal={Journal of applied physiology},
  year={2002},
  volume={93 4},
  pages={1448-56}
}
The A5 noradrenergic neurons are considered important for cardiorespiratory regulation. We hypothesized that A5 cells are silenced during rapid eye movement (REM) sleep, thereby contributing to cardiorespiratory changes and suppression of hypoglossal (XII) motoneuronal activity. We used an anesthetized, paralyzed, and artificially ventilated rat in which pontine microinjections of carbachol trigger signs of REM sleep, including hippocampal theta rhythm, motor suppression, and silencing of locus… CONTINUE READING