A431 cell variants lacking the blood group A antigen display increased high affinity epidermal growth factor-receptor number, protein-tyrosine kinase activity, and receptor turnover

@article{Defize1988A431CV,
  title={A431 cell variants lacking the blood group A antigen display increased high affinity epidermal growth factor-receptor number, protein-tyrosine kinase activity, and receptor turnover},
  author={Libert H. K. Defize and Donna J. Arndt-Jovin and Thomas M. Jovin and Johannes Boonstra and Jill Meisenhelder and Tony Hunter and H T de Hey and Siegfried W. de Laat},
  journal={The Journal of Cell Biology},
  year={1988},
  volume={107},
  pages={939 - 949}
}
The epidermal growth factor receptor (EGF-R) of human A431 cells bears an antigenic determinant that is closely related to the human blood group A carbohydrate structure. Labeling studies with blood group A reactive anti-EGF-R monoclonal antibodies and various lectins revealed that A431 cultures are heterogeneous with respect to blood group A expression. We have isolated clonal variants of these cells that either express (A431A+ cells) or completely lack (A431A- cells) the blood group A… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Structural and functional aspects of epidermal growth factor (EGF) and its receptor

  • L.H.K. Defize, S. W. de Laat
  • In Prog. Brain Res
  • 1986

versible defects in O - linked glycosylation and LDL - receptor expression in a UDP - Gal / UDP - GalNAc 4 - epimerase deficient mutant

  • R. M. Kris, J. Lax, +4 authors J. Schlessinger
  • Cell .
  • 1986

Carbohydrate structures of glycoproteins and glycolipids as differentiation antigens, tumour associated antigens and components of receptor systems

  • T. Feizi, R. A. Childs
  • Trends in Biochem
  • 1985

Similar Papers

Loading similar papers…