A3 adenosine receptors regulate Cl-channels of nonpigmented ciliary epithelial cells.

@article{Mitchell1999A3AR,
  title={A3 adenosine receptors regulate Cl-channels of nonpigmented ciliary epithelial cells.},
  author={C. Mitchell and K. Peterson-Yantorno and D. A. Carr{\'e} and A. McGlinn and M. Coca-Prados and R. Stone and M. Civan},
  journal={American journal of physiology. Cell physiology},
  year={1999},
  volume={276 3},
  pages={C659-C666}
}
Adenosine stimulates Cl- channels of the nonpigmented (NPE) cells of the ciliary epithelium. We sought to identify the specific adenosine receptors mediating this action. Cl- channel activity in immortalized human (HCE) NPE cells was determined by monitoring cell volume in isotonic suspensions with the cationic ionophore gramicidin present. The A3-selective agonist N 6-(3-iodobenzyl)-adenosine-5'- N-methyluronamide (IB-MECA) triggered shrinkage (apparent K d = 55 ± 10 nM). A3-selective… Expand
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