A2E accumulation influences retinal microglial activation and complement regulation.

@article{Ma2013A2EAI,
  title={A2E accumulation influences retinal microglial activation and complement regulation.},
  author={Wenxin Ma and Steven D Coon and Lian Zhao and Robert N Fariss and Wai T Wong},
  journal={Neurobiology of aging},
  year={2013},
  volume={34 3},
  pages={943-60}
}
Age-related macular degeneration is an outer retinal disease that involves aging and immune dysfunction. In the aging retina, microglia aggregate in the outer retina and acquire intracellular autofluorescent lipofuscin deposits. In this study, we investigated whether accumulation of A2E, a key bisretinoid constituent of ocular lipofuscin, alters the physiology of retinal microglia in pathologically relevant ways. Our findings show that sublethal accumulations of intracellular A2E in cultured… CONTINUE READING