A2B adenosine receptor blockade inhibits growth of prostate cancer cells

@article{Wei2012A2BAR,
  title={A2B adenosine receptor blockade inhibits growth of prostate cancer cells},
  author={Q. Wei and S. Costanzi and R. Balasubramanian and Zhang-Guo Gao and K. Jacobson},
  journal={Purinergic Signalling},
  year={2012},
  volume={9},
  pages={271-280}
}
The role of the A2B adenosine receptor (AR) in prostate cell death and growth was studied. The A2B AR gene expression quantified by real-time quantitative RT-PCR and Western blot analysis was the highest among four AR subtypes (A1, A2A, A2B, and A3) in all three commonly used prostate cancer cell lines, PC-3, DU145, and LNCaP. We explored the function of the A2B AR using PC-3 cells as a model. The A2B AR was visualized in PC-3 cells by laser confocal microscopy. The nonselective A2B AR agonist… Expand
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