A2A and A3 receptors mediate the adenosine-induced relaxation in spontaneously active possum duodenum in vitro.

@article{Woods2003A2AAA,
  title={A2A and A3 receptors mediate the adenosine-induced relaxation in spontaneously active possum duodenum in vitro.},
  author={Charmaine M Woods and James Toouli and G. T. P. Saccone},
  journal={British journal of pharmacology},
  year={2003},
  volume={138 7},
  pages={1333-9}
}
1. The aim of this study was to define the P1 purinergic receptors that regulate spontaneous or adenosine-induced duodenal motor activity. 2. Spontaneous contractile activity was recorded isometrically from possum longitudinal duodenal muscle strips. Adenosine (0.5 micro M-1 mM) was administered noncumulatively and repeated after pretreatment with a P1 antagonist or tetrodotoxin (TTX, 1 micro M), (n=4-7). Antagonists used were: A(1), 8-cyclopentyl-1,3-dipropylxanthine (DPCPX, 10 nM); A(2A), 8… CONTINUE READING