A2A adenosine receptors on bone marrow-derived cells protect liver from ischemia-reperfusion injury.

@article{Day2005A2AAR,
  title={A2A adenosine receptors on bone marrow-derived cells protect liver from ischemia-reperfusion injury.},
  author={Yuan-Ji Day and Yuesheng Li and Jayson M. Rieger and Susan I. Ramos and Mark Douglas Okusa and Joel M Linden},
  journal={Journal of immunology},
  year={2005},
  volume={174 8},
  pages={5040-6}
}
Activation of the A2A adenosine receptor (A(2A)R) during reperfusion of various tissues has been found to markedly reduce ischemia-reperfusion injury. In this study, we used bone marrow transplantation (BMT) to create chimeric mice that either selectively lack or selectively express the A(2A)R on bone marrow-derived cells. Bolus i.p. injection of the selective A2A agonist, 4-[3-[6-amino-9-(5-cyclopropylcarbamoyl-3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl]-piperidine-1… CONTINUE READING