A23187 increases calcium permeability of store sites more than of surface membranes in the rabbit mesenteric artery.

@article{Itoh1985A23187IC,
  title={A23187 increases calcium permeability of store sites more than of surface membranes in the rabbit mesenteric artery.},
  author={Takehiko Itoh and Yuichi Kanmura and Hirosi Kuriyama},
  journal={The Journal of physiology},
  year={1985},
  volume={359},
  pages={
          467-84
        }
}
The effects of a Ca ionophore, A23187, were investigated on intact and skinned smooth muscle tissues of the rabbit mesenteric artery. A23187 (over 10(-9) M) inhibited, dose dependently, contractions induced by 10(-5) M-noradrenaline (NA) or 10 mM-caffeine in Ca2+-free solution containing 2 mM-EGTA. Procaine (3 mM) led to cessation of the caffeine- or NA-induced contractions in the presence or absence of Ca2+. When A23187 (10(-7) M) was applied, the contractions in the presence of procaine were… CONTINUE READING

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