A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation.

@article{Daniel2004A20PE,
  title={A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation.},
  author={Soizic Daniel and Maria B. Arvelo and Virendra I. Patel and Christopher R. Longo and Gautam Shrikhande and Tala Shukri and J{\'e}r{\^o}me Mahiou and David W. Sun and Christina Mottley and Shane T. Grey and Christiane Ferran},
  journal={Blood},
  year={2004},
  volume={104 8},
  pages={2376-84}
}
A20 is a stress response gene in endothelial cells (ECs). A20 serves a dual cytoprotective function, protecting from tumor necrosis factor (TNF)-mediated apoptosis and inhibiting inflammation via blockade of the transcription factor nuclear factor-kappaB (NF-kappaB). In this study, we evaluated the molecular basis of the cytoprotective function of A20 in EC cultures and questioned whether its protective effect extends beyond TNF to other apoptotic and necrotic stimuli. Our data demonstrate that… CONTINUE READING
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cine endothelial cells , unlike human endothelial cells , can be killed by human CTL via Fas ligand and cannot be protected by Bcl - 2

  • EA Atkinson, M Barry, AJ Darmon
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