A2 and P2 purine receptor interactions and surfactant secretion in primary cultures of type II cells.

@article{Griese1991A2AP,
  title={A2 and P2 purine receptor interactions and surfactant secretion in primary cultures of type II cells.},
  author={Matthias Griese and Laurice I. Gobran and Seamus Rooney},
  journal={The American journal of physiology},
  year={1991},
  volume={261 2 Pt 1},
  pages={L140-7}
}
Phosphatidylcholine secretion in type II pneumocytes can be stimulated by P1 (adenosine) and P2 (ATP) purinoceptor agonists. The effect of adenosine is mediated by the A2 subtype of the P1 receptor. The A1 subtype is inhibitory. We examined the influence of ATP and the A2 agonist 5'-(N-ethylcarboxyamido)adenosine (NECA) on phosphatidylcholine secretion in primary cultures of rat type II cells. The stimulatory effects of ATP and NECA were less than additive, suggesting a common mechanism of… CONTINUE READING