A179L, a new viral Bcl2 homolog targeting Beclin 1 autophagy related protein.

@article{Hernez2013A179LAN,
  title={A179L, a new viral Bcl2 homolog targeting Beclin 1 autophagy related protein.},
  author={Bruno Hern{\'a}ez and Marta Cabezas and Roc{\'i}o Mu{\~n}oz-Moreno and Ignacio R. Galindo and M A Cuesta-Geijo and Covadonga Alonso Alonso},
  journal={Current molecular medicine},
  year={2013},
  volume={13 2},
  pages={305-16}
}
Autophagy is a relevant cellular defense mechanism that directly eliminates intracellular pathogens and has a crucial role for innate and adaptive immune responses. Some viruses have developed tools to counteract this cellular response. A179L, the viral Bcl2 homolog of African swine fever virus, interacts with proapoptotic Bcl2 family proteins to inhibit apoptosis. Here we report that this gene manipulates autophagy by interacting with Beclin 1 through its BH3 homology domain. At subcellular… CONTINUE READING

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