A1.13 Increased presence of CD206+ macrophage subset in peripheral blood of systemic sclerosis patients

@article{Soldano2015A113IP,
  title={A1.13 Increased presence of CD206+ macrophage subset in peripheral blood of systemic sclerosis patients},
  author={Stefano Soldano and Paola Contini and Renata Brizzolara and Paola Montagna and Alberto Sulli and Sabrina Paolino and Maurizio Cutolo},
  journal={Annals of the Rheumatic Diseases},
  year={2015},
  volume={74},
  pages={A5 - A6}
}
Background and objectives In systemic sclerosis (SSc), the immune-inflammatory infiltrate is primarily made of macrophages and T cells.1 Recently, alternatively activated macrophages (M2) have been shown to enhance fibrosis through the production of pro-fibrotic molecules (i.e. fibronectin, metalloproteinases and TGFβ.2 M2 are characterised by an increased expression of specific markers, primarily CD206 (macrophage mannose receptor-1) and macrophage scavenger receptors (CD204 and CD163). The… 

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