A1.13 Increased presence of CD206+ macrophage subset in peripheral blood of systemic sclerosis patients

  title={A1.13 Increased presence of CD206+ macrophage subset in peripheral blood of systemic sclerosis patients},
  author={Stefano Soldano and Paola Contini and Renata Brizzolara and Paola Montagna and Alberto Sulli and Sabrina Paolino and Maurizio Cutolo},
  journal={Annals of the Rheumatic Diseases},
  pages={A5 - A6}
Background and objectives In systemic sclerosis (SSc), the immune-inflammatory infiltrate is primarily made of macrophages and T cells.1 Recently, alternatively activated macrophages (M2) have been shown to enhance fibrosis through the production of pro-fibrotic molecules (i.e. fibronectin, metalloproteinases and TGFβ.2 M2 are characterised by an increased expression of specific markers, primarily CD206 (macrophage mannose receptor-1) and macrophage scavenger receptors (CD204 and CD163). The… 



Mechanisms of fibrosis: therapeutic translation for fibrotic disease

How cell-intrinsic changes in important structural cells can perpetuate the fibrotic response by regulating the differentiation, recruitment, proliferation and activation of extracellular matrix–producing myofibroblasts is described.

2013 classification criteria for systemic sclerosis: an American College of Rheumatology/European League against Rheumatism collaborative initiative.

The ACR/EULAR classification criteria for SSc performed better than the 1980 ACR criteria and should allow for more patients to be classified correctly as having the disease.