A1 receptor mediated adenosinergic regulation of perifornical-lateral hypothalamic area neurons in freely behaving rats.

@article{Rai2010A1RM,
  title={A1 receptor mediated adenosinergic regulation of perifornical-lateral hypothalamic area neurons in freely behaving rats.},
  author={Seema Rai and Sunil Kumar and Md. Aftab Alam and Ronald Szymusiak and Dennis McGinty and Md Noor Alam},
  journal={Neuroscience},
  year={2010},
  volume={167 1},
  pages={40-8}
}
The perifornical-lateral hypothalamic area (PF-LHA) plays a central role in the regulation of behavioral arousal. The PF-LHA contains several neuronal types including wake-active hypocretin (HCRT) neurons that have been implicated in the promotion and/or maintenance of behavioral arousal. Adenosine is an endogenous sleep factor and recent evidence suggests that activation and blockade of adenosine A(1) receptors within the PF-LHA promote and suppress sleep, respectively. Although, an in vitro… CONTINUE READING
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