A1 antagonism in asthma: better than coffee?

@article{Tilley2005A1AI,
  title={A1 antagonism in asthma: better than coffee?},
  author={Stephen L. Tilley and Richard C. Boucher},
  journal={The Journal of clinical investigation},
  year={2005},
  volume={115 1},
  pages={
          13-6
        }
}
Adenosine is a ubiquitous biological mediator with the capacity to produce both pro- and anti-inflammatory effects in tissues. Proinflammatory and bronchoconstrictive actions of adenosine in the asthmatic lung are well recognized, with the latter being mediated, in part, through A(1) receptor activation on airway smooth muscle. In this issue of the JCI, Sun et al. report findings in adenosine deaminase-deficient mice that suggest the occurrence of anti-inflammatory actions of adenosine in the… CONTINUE READING

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