Corpus ID: 12880873

A1- and A2-selective adenosine antagonists: in vivo characterization of cardiovascular effects.

  title={A1- and A2-selective adenosine antagonists: in vivo characterization of cardiovascular effects.},
  author={G. Evoniuk and K. Jacobson and M. Shamim and J. Daly and R. Wurtman},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={242 3},
  • G. Evoniuk, K. Jacobson, +2 authors R. Wurtman
  • Published 1987
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • Caffeine, a nonselective adenosine receptor antagonist, 7-methyl-1,3-dipropylxanthine, a purported A2 selective antagonist and a 1,3-dipropyl-8-phenylxanthine amine congener (XAC), an A1 selective antagonist, were evaluated for their in vivo selectivity at A1 vs. A2 adenosine receptors. Blockade of the negative chronotropic effect of bolus i.v. injections of 2-chloroadenosine, R-phenylisopropyladenosine and N-ethylcarboxamidoadenosine was utilized as an index of antagonism at A1 receptors… CONTINUE READING
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